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A Conserved Electrostatic Membrane-Binding Surface in Synaptotagmin-Like Proteins Revealed Using Molecular Phylogenetic Analysis and Homology Modeling

Protein structure prediction has emerged as a core technology for understanding biomolecules and their interactions. Here, we combine homology-based structure prediction with molecular phylogenetic analysis to study the evolution of electrostatic membrane binding among vertebrate synaptotagmin-like...

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Detalles Bibliográficos
Autores principales: Chon, Nara L., Tran, Sherleen, Miller, Christopher S., Lin, Hai, Knight, Jefferson D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369986/
https://www.ncbi.nlm.nih.gov/pubmed/37502952
http://dx.doi.org/10.1101/2023.07.13.548768