Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro

In mammalian cells, DNA double-strand breaks are predominantly repaired by non-homologous end joining (NHEJ). During repair, the Ku70/80 heterodimer (Ku), XRCC4 in complex with DNA Ligase 4 (X4L4), and XLF form a flexible scaffold that holds the broken DNA ends together. Insights into the architectu...

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Detalles Bibliográficos
Autores principales: Vu, Duc-Duy, Bonucci, Alessio, Brenière, Manon, Cisneros-Aguirre, Metztli, Pelupessy, Philippe, Wang, Ziqing, Carlier, Ludovic, Bouvignies, Guillaume, Cortes, Patricia, Aggarwal, Aneel K., Blackledge, Martin, Gueroui, Zoher, Belle, Valérie, Stark, Jeremy M., Modesti, Mauro, Ferrage, Fabien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369993/
https://www.ncbi.nlm.nih.gov/pubmed/37503201
http://dx.doi.org/10.1101/2023.07.12.548668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369993/
https://www.ncbi.nlm.nih.gov/pubmed/37503201
http://dx.doi.org/10.1101/2023.07.12.548668

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