Simultaneous multi-site editing of individual genomes using retron arrays

Our understanding of genomics is limited by the scale of our genomic technologies. While libraries of genomic manipulations scaffolded on CRISPR gRNAs have been transformative, these existing approaches are typically multiplexed across genomes. Yet much of the complexity of real genomes is encoded w...

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Detalles Bibliográficos
Autores principales: González-Delgado, Alejandro, Lopez, Santiago C., Rojas-Montero, Matías, Fishman, Chloe B., Shipman, Seth L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370050/
https://www.ncbi.nlm.nih.gov/pubmed/37503029
http://dx.doi.org/10.1101/2023.07.17.549397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370050/
https://www.ncbi.nlm.nih.gov/pubmed/37503029
http://dx.doi.org/10.1101/2023.07.17.549397

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