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Contextual protein and antibody encodings from equivariant graph transformers

The optimal residue identity at each position in a protein is determined by its structural, evolutionary, and functional context. We seek to learn the representation space of the optimal amino-acid residue in different structural contexts in proteins. Inspired by masked language modeling (MLM), our...

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Detalles Bibliográficos
Autores principales: Mahajan, Sai Pooja, Ruffolo, Jeffrey A., Gray, Jeffrey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370091/
https://www.ncbi.nlm.nih.gov/pubmed/37503113
http://dx.doi.org/10.1101/2023.07.15.549154