Complete Protection from SARS-CoV-2 Lung Infection in Mice Through Combined Intranasal Delivery of PIKfyve Kinase and TMPRSS2 Protease Inhibitors

Emerging variants of concern of SARS-CoV-2 can significantly reduce the prophylactic and therapeutic efficacy of vaccines and neutralizing antibodies due to mutations in the viral genome. Targeting cell host factors required for infection provides a complementary strategy to overcome this problem si...

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Detalles Bibliográficos
Autores principales: Kant, Ravi, Kareinen, Lauri, Ojha, Ravi, Strandin, Tomas, Saber, Saber Hassan, Lesnikova, Angelina, Kuivanen, Suvi, Sirnonen, Tarja, Joensuu, Merja, Vapalahti, Olli, Kirchhausen, Tom, Kipar, Anja, Balistreri, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370096/
https://www.ncbi.nlm.nih.gov/pubmed/37503261
http://dx.doi.org/10.1101/2023.07.19.549731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370096/
https://www.ncbi.nlm.nih.gov/pubmed/37503261
http://dx.doi.org/10.1101/2023.07.19.549731

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