Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth

AML is a heterogenous disease caused by different mutations. We have previously shown that each mutational sub-type develops its specific gene regulatory network (GRN) with transcription factors interacting with multiple gene modules, many of which are transcription factor genes themselves. Here we...

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Detalles Bibliográficos
Autores principales: Coleman, Daniel J.L., Keane, Peter, Luque-Martin, Rosario, Chin, Paulynn S, Blair, Helen, Ames, Luke, Kellaway, Sophie G., Griffin, James, Holmes, Elizabeth, Potluri, Sandeep, Assi, Salam A., Bushweller, John, Heidenreich, Olaf, Cockerill, Peter N., Bonifer, Constanze
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370108/
https://www.ncbi.nlm.nih.gov/pubmed/37503022
http://dx.doi.org/10.1101/2023.07.18.549495

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