Phase separation of ecDNA aggregates establishes in-trans contact domains boosting selective MYC regulatory interactions

Extrachromosomal DNAs (ecDNAs) are found in the nucleus of an array of human cancer cells where they can form clusters that were associated to oncogene overexpression, as they carry genes and cis-regulatory elements. Yet, the mechanisms of aggregation and gene amplification beyond copy-number effect...

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Detalles Bibliográficos
Autores principales: Conte, Mattia, Matteuzzi, Tommaso, Esposito, Andrea, Chiariello, Andrea M., Bianco, Simona, Vercellone, Francesca, Nicodemi, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370113/
https://www.ncbi.nlm.nih.gov/pubmed/37503084
http://dx.doi.org/10.1101/2023.07.17.549291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370113/
https://www.ncbi.nlm.nih.gov/pubmed/37503084
http://dx.doi.org/10.1101/2023.07.17.549291

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