The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neurons

Idiopathic Parkinson’s Disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, which is associated with neuroinflammation and reactive gliosis. The underlying cause of PD and the concurrent neuroinflammation are not well understood. In this study, we...

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Detalles Bibliográficos
Autores principales: Russo, Taylor, Kolisnyk, Benjamin, Aswathy, BS, Wan Kim, Tae, Martin, Jacqueline, Plessis-Belair, Jonathan, Ni, Jason, Pearson, Jordan A., Park, Emily J., Sher, Roger B., Studer, Lorenz, Riessland, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370136/
https://www.ncbi.nlm.nih.gov/pubmed/37503189
http://dx.doi.org/10.1101/2023.07.19.549710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370136/
https://www.ncbi.nlm.nih.gov/pubmed/37503189
http://dx.doi.org/10.1101/2023.07.19.549710

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