A highly enantioselective intramolecular 1,3-dipolar cycloaddition yields novel pseudo-natural product inhibitors of the Hedgehog signalling pathway

De novo combination of natural product (NP) fragments by means of efficient, complexity- and stereogenic character-generating transformations to yield pseudo-natural products (PNPs) may explore novel biologically relevant chemical space. Pyrrolidine- and tetrahydroquinoline fragments rarely occur in...

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Detalles Bibliográficos
Autores principales: Liu, Jie, Zhang, Ruirui, Mallick, Shubhadip, Patil, Sohan, Wientjens, Chantal, Flegel, Jana, Krupp, Anna, Strohmann, Carsten, Grassin, Corentin, Merten, Christian, Pahl, Axel, Grigalunas, Michael, Waldmann, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370549/
https://www.ncbi.nlm.nih.gov/pubmed/37502335
http://dx.doi.org/10.1039/d3sc01240a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370549/
https://www.ncbi.nlm.nih.gov/pubmed/37502335
http://dx.doi.org/10.1039/d3sc01240a

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