Small molecule antagonists of PTPmu identified by artificial intelligence-based computational screening block glioma cell migration and growth

PTPmu (PTPμ) is a member of the receptor protein tyrosine phosphatase IIb family that participates in both homophilic cell-cell adhesion and signaling. PTPmu is proteolytically downregulated in glioblastoma generating extracellular and intracellular fragments that have oncogenic activity. The intrac...

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Detalles Bibliográficos
Autores principales: Molyneaux, Kathleen, Laggner, Christian, Vincent, Jason, Brady-Kalnay, Susann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370706/
https://www.ncbi.nlm.nih.gov/pubmed/37494327
http://dx.doi.org/10.1371/journal.pone.0288980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370706/
https://www.ncbi.nlm.nih.gov/pubmed/37494327
http://dx.doi.org/10.1371/journal.pone.0288980

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