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RNase H genes cause distinct impacts on RNA:DNA hybrid formation and mutagenesis genome wide
RNA:DNA hybrids compromise replication fork progression and genome integrity in all cells. The overall impacts of naturally occurring RNA:DNA hybrids on genome integrity, and the relative contributions of ribonucleases H to mitigating the negative effects of hybrids, remain unknown. Here, we investi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371020/ https://www.ncbi.nlm.nih.gov/pubmed/37494439 http://dx.doi.org/10.1126/sciadv.adi5945 |