RNase H genes cause distinct impacts on RNA:DNA hybrid formation and mutagenesis genome wide

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RNA:DNA hybrids compromise replication fork progression and genome integrity in all cells. The overall impacts of naturally occurring RNA:DNA hybrids on genome integrity, and the relative contributions of ribonucleases H to mitigating the negative effects of hybrids, remain unknown. Here, we investi...

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Detalles Bibliográficos
Autores principales: Schroeder, Jeremy W., Hurto, Rebecca L., Randall, Justin R., Wozniak, Katherine J., Timko, Taylor A., Nye, Taylor M., Wang, Jue D., Freddolino, Peter L., Simmons, Lyle A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371020/
https://www.ncbi.nlm.nih.gov/pubmed/37494439
http://dx.doi.org/10.1126/sciadv.adi5945
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