Phosphorylated nuclear DICER1 promotes open chromatin state and lineage plasticity of AT2 tumor cells in lung adenocarcinomas

KRAS/ERK pathway phosphorylates DICER1, causing its nuclear translocation, and phosphomimetic Dicer1 contributes to tumorigenesis in mice. Mechanisms through which phospho-DICER1 regulates tumor progression remain undefined. While DICER1 canonically regulates microRNAs (miRNA) and epithelial-to-mese...

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Detalles Bibliográficos
Autores principales: Reyes-Castro, Raisa A., Chen, Shin-Yu, Seemann, Jacob, Kundu, Samrat T., Gibbons, Don L., Arur, Swathi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371025/
https://www.ncbi.nlm.nih.gov/pubmed/37494452
http://dx.doi.org/10.1126/sciadv.adf6210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371025/
https://www.ncbi.nlm.nih.gov/pubmed/37494452
http://dx.doi.org/10.1126/sciadv.adf6210

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