Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in murine Alzheimer’s disease

BACKGROUND: Cognitive decline in Alzheimer’s disease (AD) is associated with prion-like tau propagation between neurons along synaptically connected networks, in part via extracellular vesicles (EV). EV biogenesis is triggered by ceramide enrichment at the plasma membrane from neutral sphingomyelina...

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Detalles Bibliográficos
Autores principales: Tallon, Carolyn, Bell, Benjamin J, Malvankar, Medhinee M, Deme, Pragney, Nogueras-Ortiz, Carlos, Eren, Erden, Thomas, Ajit G, Hollinger, Kristen R, Pal, Arindom, Mustapic, Maja, Huang, Meixiang, Coleman, Kaleem, Joe, Tawnjerae R, Rais, Rana, Haughey, Norman J, Kapogiannis, Dimitrios, Slusher, Barbara S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371082/
https://www.ncbi.nlm.nih.gov/pubmed/37502930
http://dx.doi.org/10.21203/rs.3.rs-3131295/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371082/
https://www.ncbi.nlm.nih.gov/pubmed/37502930
http://dx.doi.org/10.21203/rs.3.rs-3131295/v1

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