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Glucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain
Chronic stress and elevated levels of glucocorticoids (GCs), the main stress hormones, accelerate Alzheimer’s disease (AD) onset and progression. A major driver of AD progression is the spreading of pathogenic Tau protein between brain regions, precipitated by neuronal Tau secretion. While stress an...
Autores principales: | Waites, Clarissa, Yu, Qing, Du, Fang, Belli, Irla, Gomes, Patrícia, Sotiropoulos, Ioannis |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Journal Experts
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371092/ https://www.ncbi.nlm.nih.gov/pubmed/37503224 http://dx.doi.org/10.21203/rs.3.rs-3097174/v1 |
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