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APOE-ε4 and BIN1 increase risk of Alzheimer’s disease pathology but not specifically of Lewy body pathology

Lewy body (LB) pathology commonly occurs in individuals with Alzheimer’s disease (AD) pathology. However, it remains unclear which genetic risk factors underlie AD pathology, LB pathology, or AD-LB co-pathology. Notably, whether APOE-ε4 affects risk of LB pathology independently from AD pathology is...

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Detalles Bibliográficos
Autores principales: Talyansky, Seth, Guen, Yann Le, Kasireddy, Nandita, Belloy, Michael E., Greicius, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371184/
https://www.ncbi.nlm.nih.gov/pubmed/37503074
http://dx.doi.org/10.1101/2023.04.21.23288938