Leveraging genetic diversity to identify small molecules that reverse mouse skeletal muscle insulin resistance

Systems genetics has begun to tackle the complexity of insulin resistance by capitalising on computational advances to study high-diversity populations. ‘Diversity Outbred in Australia (DOz)’ is a population of genetically unique mice with profound metabolic heterogeneity. We leveraged this variance...

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Detalles Bibliográficos
Autores principales: Masson, Stewart WC, Madsen, Søren, Cooke, Kristen C, Potter, Meg, Vegas, Alexis Diaz, Carroll, Luke, Thillainadesan, Senthil, Cutler, Harry B, Walder, Ken R, Cooney, Gregory J, Morahan, Grant, Stöckli, Jacqueline, James, David E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371229/
https://www.ncbi.nlm.nih.gov/pubmed/37494090
http://dx.doi.org/10.7554/eLife.86961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371229/
https://www.ncbi.nlm.nih.gov/pubmed/37494090
http://dx.doi.org/10.7554/eLife.86961

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