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Searching for molecular hypoxia sensors among oxygen-dependent enzymes

The ability to sense and respond to changes in cellular oxygen levels is critical for aerobic organisms and requires a molecular oxygen sensor. The prototypical sensor is the oxygen-dependent enzyme PHD: hypoxia inhibits its ability to hydroxylate the transcription factor HIF, causing HIF to accumul...

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Detalles Bibliográficos
Autores principales:	Li, Li, Shen, Susan, Bickler, Philip, Jacobson, Matthew P, Wu, Lani F, Altschuler, Steven J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371230/ https://www.ncbi.nlm.nih.gov/pubmed/37494095 http://dx.doi.org/10.7554/eLife.87705

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