The proto-oncogene SRC phosphorylates cGAS to inhibit an antitumor immune response

Cyclic GMP-AMP synthase (cGAS) is a DNA sensor and responsible for inducing an antitumor immune response. Recent studies reveal that cGAS is frequently inhibited in cancer, and therapeutic targets to promote antitumor cGAS function remain elusive. SRC is a proto-oncogene tyrosine kinase and is expre...

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Detalles Bibliográficos
Autores principales: Dunker, William, Zaver, Shivam A., Pineda, Jose Mario Bello, Howard, Cameron J., Bradley, Robert K., Woodward, Joshua J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371251/
https://www.ncbi.nlm.nih.gov/pubmed/37166992
http://dx.doi.org/10.1172/jci.insight.167270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371251/
https://www.ncbi.nlm.nih.gov/pubmed/37166992
http://dx.doi.org/10.1172/jci.insight.167270

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