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CyclosporinA Derivative as Therapeutic Candidate for Alport Syndrome by Inducing Mutant Type IV Collagen Secretion
KEY POINTS: Screening of natural product extracts to find candidate compounds that increase mutant type IV collagen α3,4,5 (α345(IV)) trimer secretion in Alport syndrome (AS). Cyclosporin A (CsA) and alisporivir (ALV) increase mutant α345(IV) trimer secretion in AS. PPIF/cyclophilin D mediates the e...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Nephrology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371266/ https://www.ncbi.nlm.nih.gov/pubmed/37143203 http://dx.doi.org/10.34067/KID.0000000000000134 |