CyclosporinA Derivative as Therapeutic Candidate for Alport Syndrome by Inducing Mutant Type IV Collagen Secretion

KEY POINTS: Screening of natural product extracts to find candidate compounds that increase mutant type IV collagen α3,4,5 (α345(IV)) trimer secretion in Alport syndrome (AS). Cyclosporin A (CsA) and alisporivir (ALV) increase mutant α345(IV) trimer secretion in AS. PPIF/cyclophilin D mediates the e...

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Detalles Bibliográficos
Autores principales: Kuwazuru, Jun, Suico, Mary Ann, Omachi, Kohei, Kojima, Haruka, Kamura, Misato, Kaseda, Shota, Kawahara, Teppei, Hitora, Yuki, Kato, Hikaru, Tsukamoto, Sachiko, Wada, Mikiyo, Asano, Toshifumi, Kotani, Shunsuke, Nakajima, Makoto, Misumi, Shogo, Sannomiya, Yuya, Horizono, Jun, Koyama, Yuimi, Owaki, Aimi, Shuto, Tsuyoshi, Kai, Hirofumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Nephrology 2023
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371266/
https://www.ncbi.nlm.nih.gov/pubmed/37143203
http://dx.doi.org/10.34067/KID.0000000000000134

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