Immunosurveillance shapes the emergence of neo-epitope landscapes of sarcomas, revealing prime targets for immunotherapy

T cells recognize tumor-derived mutated peptides presented on MHC by tumors. The recognition of these neo-epitopes leads to rejection of tumors, an event that is critical for successful cancer immunosurveillance. Determination of tumor-rejecting neo-epitopes in human tumors has proved difficult, tho...

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Detalles Bibliográficos
Autores principales: Osei-Hwedieh, David O., Sedlacek, Abigail L., Hernandez, Luis Mena, Yamoah, Archibald Agyekum, Iyer, Swati G., Weiss, Kurt R., Binder, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371341/
https://www.ncbi.nlm.nih.gov/pubmed/37427594
http://dx.doi.org/10.1172/jci.insight.170324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371341/
https://www.ncbi.nlm.nih.gov/pubmed/37427594
http://dx.doi.org/10.1172/jci.insight.170324

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