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Reprogramming of PD-1(+) M2-like tumor-associated macrophages with anti–PD-L1 and lenalidomide in cutaneous T cell lymphoma

Cutaneous T cell lymphoma (CTCL) is a disfiguring and incurable disease characterized by skin-homing malignant T cells surrounded by immune cells that promote CTCL growth through an immunosuppressive tumor microenvironment (TME). Preliminary data from our phase I clinical trial of anti–programmed ce...

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Detalles Bibliográficos
Autores principales: Han, Zhen, Wu, Xiwei, Qin, Hanjun, Yuan, Yate-Ching, Schmolze, Daniel, Su, Chingyu, Zain, Jasmine, Moyal, Lilach, Hodak, Emmilia, Sanchez, James F., Lee, Peter P., Feng, Mingye, Rosen, Steven T., Querfeld, Christiane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371344/
https://www.ncbi.nlm.nih.gov/pubmed/37427589
http://dx.doi.org/10.1172/jci.insight.163518