Ablation of C-type natriuretic peptide/cGMP signaling in fibroblasts exacerbates adverse cardiac remodeling in mice

Excessive activation of cardiac fibroblasts (CFs) in response to injury provokes cardiac fibrosis, stiffness, and failure. The local mediators counterregulating this response remain unclear. Exogenous C-type natriuretic peptide (CNP) exerts antifibrotic effects in preclinical models. To unravel the...

Descripción completa

Detalles Bibliográficos
Autores principales: Werner, Franziska, Prentki Santos, Estefania, Michel, Konstanze, Schrader, Hanna, Völker, Katharina, Potapenko, Tamara, Krebes, Lisa, Abeßer, Marco, Möllmann, Dorothe, Schlattjan, Martin, Schmidt, Hannes, Skryabin, Boris V., Špiranec Spes, Katarina, Schuh, Kai, Denton, Christopher P., Baba, Hideo A., Kuhn, Michaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371345/
https://www.ncbi.nlm.nih.gov/pubmed/37227779
http://dx.doi.org/10.1172/jci.insight.160416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371345/
https://www.ncbi.nlm.nih.gov/pubmed/37227779
http://dx.doi.org/10.1172/jci.insight.160416

Ejemplares similares