Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth

The mammalian target of rapamycin complex 1 (mTORC1) senses multiple upstream stimuli to orchestrate anabolic and catabolic events that regulate cell growth and metabolism. Hyperactivation of mTORC1 signaling is observed in multiple human diseases; thus, pathways that suppress mTORC1 signaling may h...

Descripción completa

Detalles Bibliográficos
Autores principales: Jeong, Mi-Hyeon, Urquhart, Greg, Lewis, Cheryl, Chi, Zhikai, Jewell, Jenna L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371348/
https://www.ncbi.nlm.nih.gov/pubmed/37427586
http://dx.doi.org/10.1172/jci.insight.158098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371348/
https://www.ncbi.nlm.nih.gov/pubmed/37427586
http://dx.doi.org/10.1172/jci.insight.158098

Ejemplares similares