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Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth

The mammalian target of rapamycin complex 1 (mTORC1) senses multiple upstream stimuli to orchestrate anabolic and catabolic events that regulate cell growth and metabolism. Hyperactivation of mTORC1 signaling is observed in multiple human diseases; thus, pathways that suppress mTORC1 signaling may h...

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Detalles Bibliográficos
Autores principales:	Jeong, Mi-Hyeon, Urquhart, Greg, Lewis, Cheryl, Chi, Zhikai, Jewell, Jenna L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371348/ https://www.ncbi.nlm.nih.gov/pubmed/37427586 http://dx.doi.org/10.1172/jci.insight.158098

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