The TLR7/IRF-5 axis sensitizes memory CD4(+) T cells to Fas-mediated apoptosis during HIV-1 infection

HIV-1 infection is characterized by inflammation and a progressive decline in CD4(+) T cell count. Despite treatment with antiretroviral therapy (ART), the majority of people living with HIV (PLWH) maintain residual levels of inflammation, a low degree of immune activation, and higher sensitivity to...

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Detalles Bibliográficos
Autores principales: Carmona-Pérez, Liseth, Dagenais-Lussier, Xavier, Mai, Linh T., Stögerer, Tanja, Swaminathan, Sharada, Isnard, Stéphane, Rice, Matthew R., Barnes, Betsy J., Routy, Jean-Pierre, van Grevenynghe, Julien, Stäger, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371351/
https://www.ncbi.nlm.nih.gov/pubmed/37227774
http://dx.doi.org/10.1172/jci.insight.167329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371351/
https://www.ncbi.nlm.nih.gov/pubmed/37227774
http://dx.doi.org/10.1172/jci.insight.167329

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