Cargando…

The TLR7/IRF-5 axis sensitizes memory CD4(+) T cells to Fas-mediated apoptosis during HIV-1 infection

HIV-1 infection is characterized by inflammation and a progressive decline in CD4(+) T cell count. Despite treatment with antiretroviral therapy (ART), the majority of people living with HIV (PLWH) maintain residual levels of inflammation, a low degree of immune activation, and higher sensitivity to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Carmona-Pérez, Liseth, Dagenais-Lussier, Xavier, Mai, Linh T., Stögerer, Tanja, Swaminathan, Sharada, Isnard, Stéphane, Rice, Matthew R., Barnes, Betsy J., Routy, Jean-Pierre, van Grevenynghe, Julien, Stäger, Simona
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371351/ https://www.ncbi.nlm.nih.gov/pubmed/37227774 http://dx.doi.org/10.1172/jci.insight.167329

Ejemplares similares

Leishmania donovani Exploits Tunneling Nanotubes for Dissemination and Propagation of B Cell Activation
por: Stögerer, Tanja, et al.
Publicado: (2023)

Innate Immune Sensing by Cells of the Adaptive Immune System
por: Stögerer, Tanja, et al.
Publicado: (2020)

Sustained IFN-I Expression during Established Persistent Viral Infection: A “Bad Seed” for Protective Immunity
por: Dagenais-Lussier, Xavier, et al.
Publicado: (2017)

USP18 is a significant driver of memory CD4 T-cell reduced viability caused by type I IFN signaling during primary HIV-1 infection
por: Dagenais-Lussier, Xavier, et al.
Publicado: (2019)

IRF-5 Expression in Myeloid Cells Is Required for Splenomegaly in L. donovani Infected Mice
por: Mai, Linh Thuy, et al.
Publicado: (2020)

Harnessing Autophagy to Overcome Antigen-Specific T-Cell Dysfunction: Implication for People Living with HIV-1
por: Ghahari, Nazanin, et al.
Publicado: (2023)

Cannabinoid-Induced Immunomodulation during Viral Infections: A Focus on Mitochondria
por: Beji, Cherifa, et al.
Publicado: (2020)

Potential T Cell-Intrinsic Regulatory Roles for IRF5 via Cytokine Modulation in T Helper Subset Differentiation and Function
por: Brune, Zarina, et al.
Publicado: (2020)

B Cell-Intrinsic Role for IRF5 in TLR9/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation
por: De, Saurav, et al.
Publicado: (2018)

Critical Role of IRF-5 in the Development of T helper 1 responses to Leishmania donovani infection
por: Paun, Andrea, et al.
Publicado: (2011)

LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF
por: Fitzgerald, Katherine A., et al.
Publicado: (2003)

Therapeutic Targeting of IRFs: Pathway-Dependence or Structure-Based?
por: Thompson, Cherrie D., et al.
Publicado: (2018)

Beyond the Absence of CD4 T-Cell Count: A Novel Genetic CD4 T-Cell Deficiency Disorder With a Contingency Plan
por: Routy, Jean-Pierre, et al.
Publicado: (2021)

Never say “never the twain shall meet”: Combining antiretroviral therapy and RNA vaccine to obtain an adequate humoral immune response in people living with HIV
por: Routy, Jean-Pierre, et al.
Publicado: (2022)

IRF-5-Mediated Inflammation Limits CD8(+) T Cell Expansion by Inducing HIF-1α and Impairing Dendritic Cell Functions during Leishmania Infection
por: Hammami, Akil, et al.
Publicado: (2015)

Swine IRF3/IRF7 attenuates inflammatory responses through TLR4 signaling pathway
por: Chen, Pei-Ge, et al.
Publicado: (2017)

Targeting IRF5 inhibition in human B cells: identification of new functional roles that implicate IRF5 in systemic lupus erythematosus B-cell pathology
por: De, Saurav, et al.
Publicado: (2014)

HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections
por: Sun, Lei, et al.
Publicado: (2017)

Following the elite: Targeting immunometabolism to limit HIV pathogenesis
por: Routy, Jean-Pierre, et al.
Publicado: (2019)

GDF15/GFRAL Pathway as a Metabolic Signature for Cachexia in Patients with Cancer
por: Ahmed, Darakhshan Sohail, et al.
Publicado: (2021)

RNA-Seq for Enrichment and Analysis of IRF5 Transcript Expression in SLE
por: Stone, Rivka C., et al.
Publicado: (2013)

Specific detection of interferon regulatory factor 5 (IRF5): A case of antibody inequality
por: Li, Dan, et al.
Publicado: (2016)

Cytomegalovirus as an Uninvited Guest in the Response to Vaccines in People Living with HIV
por: Royston, Léna, et al.
Publicado: (2021)

Use of various immunotherapies for refractory ulcerative colitis in a person living with HIV: a case report
por: Costiniuk, Cecilia T, et al.
Publicado: (2021)

Control of porphyria cutanea tarda with anti-IL-17 secukinumab in a person with psoriasis living with HIV
por: Bedier, Helbies, et al.
Publicado: (2023)

A phospho-tyrosine–based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity
por: Tawaratsumida, Kazuki, et al.
Publicado: (2022)

Detection of neutrophil extracellular traps in patient plasma: method development and validation in systemic lupus erythematosus and healthy donors that carry IRF5 genetic risk
por: Matta, Bharati, et al.
Publicado: (2022)

Inborn errors underlying herpes simplex encephalitis: From TLR3 to IRF3
por: Zhang, Shen-Ying, et al.
Publicado: (2015)

ATP128 Clinical Therapeutic Cancer Vaccine Activates NF-κB and IRF3 Pathways through TLR4 and TLR2 in Human Monocytes and Dendritic Cells
por: Pascolutti, Roberta, et al.
Publicado: (2022)

TLR4 dependent heparan sulphate-induced pancreatic inflammatory response is IRF3-mediated
por: Akbarshahi, Hamid, et al.
Publicado: (2011)

Metformin effect on gut microbiota: insights for HIV-related inflammation
por: Ouyang, Jing, et al.
Publicado: (2020)

The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability
por: Henkler, Frank, et al.
Publicado: (2005)

TRIpartite Motif 21 (TRIM21) Differentially Regulates the Stability of Interferon Regulatory Factor 5 (IRF5) Isoforms
por: Lazzari, Elisa, et al.
Publicado: (2014)

CD36 neutralisation blunts TLR2-IRF7 but not IRF3 pathway in neonatal mouse brain and immature human microglia following innate immune challenge
por: Gadagkar, Shruti Gururaj, et al.
Publicado: (2023)

Loss of interferon regulatory factor 5 (IRF5) expression in human ductal carcinoma correlates with disease stage and contributes to metastasis
por: Bi, Xiaohui, et al.
Publicado: (2011)

Sex differences in the percentage of IRF5 positive B cells are associated with higher production of TNF-α in women in response to TLR9 in humans
por: Beisel, Claudia, et al.
Publicado: (2023)

TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9
por: Heinz, Leonhard X., et al.
Publicado: (2020)

TIRAP/Mal Positively Regulates TLR8-Mediated Signaling via IRF5 in Human Cells
por: Nilsen, Kaja Elisabeth, et al.
Publicado: (2022)

TLR-4, TLR-5 and IRF4 are diagnostic markers of knee osteoarthritis in the middle-aged and elderly patients and related to disease activity and inflammatory factors
por: Han, Wenchao, et al.
Publicado: (2020)

Gut Leakage of Fungal‐Related Products: Turning Up the Heat for HIV Infection
por: Isnard, Stéphane, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_af8651h959kr6cheni8a4qjkp6