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Decay-Accelerating Factor Restrains Complement Activation and Delays Progression of Murine cBSA-Induced Membranous Nephropathy
KEY POINTS: In a murine model of cationic bovine serum albumin (cBSA)–induced membranous nephropathy (MN), complement regulator decay-accelerating factor is upregulated and restrains complement activation. Studies using genetic deletion or pharmacological antagonism of C3aR indicate that the main ef...
Autores principales: | Budge, Kelly L, Verlato, Alberto, Bin, Sofia, Salem, Fadi E., Perin, Laura, La Manna, Gaetano, Zaza, Gianluigi, Fiaccadori, Enrico, Cantarelli, Chiara, Cravedi, Paolo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Nephrology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371372/ https://www.ncbi.nlm.nih.gov/pubmed/37036696 http://dx.doi.org/10.34067/KID.0000000000000122 |
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