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AAV-GRN partially corrects motor deficits and ALS/FTLD-related pathology in Tmem106b(−/−)Grn(−/−) mice
Loss of function of progranulin (PGRN), encoded by the granulin (GRN) gene, is implicated in several neurodegenerative diseases. Several therapeutics to boost PGRN levels are currently in clinical trials. However, it is difficult to test the efficacy of PGRN-enhancing drugs in mouse models due to th...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371829/ https://www.ncbi.nlm.nih.gov/pubmed/37519899 http://dx.doi.org/10.1016/j.isci.2023.107247 |