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AAV-GRN partially corrects motor deficits and ALS/FTLD-related pathology in Tmem106b(−/−)Grn(−/−) mice

Loss of function of progranulin (PGRN), encoded by the granulin (GRN) gene, is implicated in several neurodegenerative diseases. Several therapeutics to boost PGRN levels are currently in clinical trials. However, it is difficult to test the efficacy of PGRN-enhancing drugs in mouse models due to th...

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Detalles Bibliográficos
Autores principales:	Feng, Tuancheng, Minevich, Gregory, Liu, Pengan, Qin, Henry Xin, Wozniak, Glenn, Pham, Jenny, Pham, Khanh, Korgaonkar, Akshata, Kurnellas, Michael, Defranoux, Nadine A., Long, Hua, Mitra, Ananya, Hu, Fenghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371829/ https://www.ncbi.nlm.nih.gov/pubmed/37519899 http://dx.doi.org/10.1016/j.isci.2023.107247

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