Cysteines 1078 and 2991 cross-linking plays a critical role in redox regulation of cardiac ryanodine receptor (RyR)

The most common cardiac pathologies, such as myocardial infarction and heart failure, are associated with oxidative stress. Oxidation of the cardiac ryanodine receptor (RyR2) Ca(2+) channel causes spontaneous oscillations of intracellular Ca(2+), resulting in contractile dysfunction and arrhythmias....

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Detalles Bibliográficos
Autores principales: Nikolaienko, Roman, Bovo, Elisa, Kahn, Daniel, Gracia, Ryan, Jamrozik, Thomas, Zima, Aleksey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372021/
https://www.ncbi.nlm.nih.gov/pubmed/37495581
http://dx.doi.org/10.1038/s41467-023-40268-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372021/
https://www.ncbi.nlm.nih.gov/pubmed/37495581
http://dx.doi.org/10.1038/s41467-023-40268-z

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