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Enhancing tylosin production by combinatorial overexpression of efflux, SAM biosynthesis, and regulatory genes in hyperproducing Streptomyces xinghaiensis strain

Tylosin is a 16-membered macrolide antibiotic widely used in veterinary medicine to control infections caused by Gram-positive pathogens and mycoplasmas. To improve the fermentation titer of tylosin in the hyperproducing Streptomyces xinghaiensis strain TL01, we sequenced its whole genome and identi...

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Detalles Bibliográficos
Autores principales:	Dai, Penghui, Qin, Yuyao, Li, Luyuan, Li, Haidi, Lv, Lihuo, Xu, Danying, Song, Yuqing, Huang, Tingting, Lin, Shuangjun, Deng, Zixin, Tao, Meifeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	KeAi Publishing 2023
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372049/ https://www.ncbi.nlm.nih.gov/pubmed/37519989 http://dx.doi.org/10.1016/j.synbio.2023.07.002

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