DNA framework-engineered chimeras platform enables selectively targeted protein degradation

A challenge in developing proteolysis targeting chimeras (PROTACs) is the establishment of a universal platform applicable in multiple scenarios for precise degradation of proteins of interest (POIs). Inspired by the addressability, programmability, and rigidity of DNA frameworks, we develop covalen...

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Detalles Bibliográficos
Autores principales: Zhou, Li, Yu, Bin, Gao, Mengqiu, Chen, Rui, Li, Zhiyu, Gu, Yueqing, Bian, Jinlei, Ma, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372072/
https://www.ncbi.nlm.nih.gov/pubmed/37495569
http://dx.doi.org/10.1038/s41467-023-40244-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372072/
https://www.ncbi.nlm.nih.gov/pubmed/37495569
http://dx.doi.org/10.1038/s41467-023-40244-7

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