An intranasal vaccine comprising SARS-CoV-2 spike receptor-binding domain protein entrapped in mannose-conjugated chitosan nanoparticle provides protection in hamsters

We developed a novel intranasal SARS-CoV-2 subunit vaccine called NARUVAX-C19/Nano based on the spike protein receptor-binding domain (RBD) entrapped in mannose-conjugated chitosan nanoparticles (NP). A toll-like receptor 9 agonist, CpG55.2, was also added as an adjuvant to see if this would potenti...

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Detalles Bibliográficos
Autores principales: Tabynov, Kairat, Solomadin, Maxim, Turebekov, Nurkeldi, Babayeva, Meruert, Fomin, Gleb, Yadagiri, Ganesh, Renu, Sankar, Yerubayev, Toktassyn, Petrovsky, Nikolai, Renukaradhya, Gourapura J., Tabynov, Kaissar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372096/
https://www.ncbi.nlm.nih.gov/pubmed/37495639
http://dx.doi.org/10.1038/s41598-023-39402-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372096/
https://www.ncbi.nlm.nih.gov/pubmed/37495639
http://dx.doi.org/10.1038/s41598-023-39402-0

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