Rational engineering of an elevator-type metal transporter ZIP8 reveals a conditional selectivity filter critically involved in determining substrate specificity

Engineering of transporters to alter substrate specificity as desired holds great potential for applications, including metabolic engineering. However, the lack of knowledge on molecular mechanisms of substrate specificity hinders designing effective strategies for transporter engineering. Here, we...

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Detalles Bibliográficos
Autores principales: Jiang, Yuhan, Li, Zhen, Sui, Dexin, Sharma, Gaurav, Wang, Tianqi, MacRenaris, Keith, Takahashi, Hideki, Merz, Kenneth, Hu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372143/
https://www.ncbi.nlm.nih.gov/pubmed/37495662
http://dx.doi.org/10.1038/s42003-023-05146-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372143/
https://www.ncbi.nlm.nih.gov/pubmed/37495662
http://dx.doi.org/10.1038/s42003-023-05146-w

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