Chronic activation of human cardiac fibroblasts in vitro attenuates the reversibility of the myofibroblast phenotype

Activation of cardiac fibroblasts and differentiation to myofibroblasts underlies development of pathological cardiac fibrosis, leading to arrhythmias and heart failure. Myofibroblasts are characterised by increased α-smooth muscle actin (α-SMA) fibre expression, secretion of collagens and changes i...

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Detalles Bibliográficos
Autores principales: Hall, Caitlin, Law, Jonathan P., Reyat, Jasmeet S., Cumberland, Max J., Hang, Shaun, Vo, Nguyen T. N., Raniga, Kavita, Weston, Chris J., O’Shea, Christopher, Townend, Jonathan N., Gehmlich, Katja, Ferro, Charles J., Denning, Chris, Pavlovic, Davor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372150/
https://www.ncbi.nlm.nih.gov/pubmed/37495732
http://dx.doi.org/10.1038/s41598-023-39369-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372150/
https://www.ncbi.nlm.nih.gov/pubmed/37495732
http://dx.doi.org/10.1038/s41598-023-39369-y

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