Regulatory sites in the Mon1–Ccz1 complex control Rab5 to Rab7 transition and endosome maturation

Maturation from early to late endosomes depends on the exchange of their marker proteins Rab5 to Rab7. This requires Rab7 activation by its specific guanine nucleotide exchange factor (GEF) Mon1–Ccz1. Efficient GEF activity of this complex on membranes depends on Rab5, thus driving Rab–GTPase exchan...

Descripción completa

Detalles Bibliográficos
Autores principales: Borchers, Ann-Christin, Janz, Maren, Schäfer, Jan-Hannes, Moeller, Arne, Kümmel, Daniel, Paululat, Achim, Ungermann, Christian, Langemeyer, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372576/
https://www.ncbi.nlm.nih.gov/pubmed/37463208
http://dx.doi.org/10.1073/pnas.2303750120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372576/
https://www.ncbi.nlm.nih.gov/pubmed/37463208
http://dx.doi.org/10.1073/pnas.2303750120

Ejemplares similares