Changing protein–DNA interactions promote ORC binding-site exchange during replication origin licensing

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During origin licensing, the eukaryotic replicative helicase Mcm2-7 forms head-to-head double hexamers to prime origins for bidirectional replication. Recent single-molecule and structural studies revealed that one molecule of the helicase loader ORC (origin recognition complex) can sequentially loa...

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Detalles Bibliográficos
Autores principales: Zhang, Annie, Friedman, Larry J., Gelles, Jeff, Bell, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372627/
https://www.ncbi.nlm.nih.gov/pubmed/37463200
http://dx.doi.org/10.1073/pnas.2305556120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372627/
https://www.ncbi.nlm.nih.gov/pubmed/37463200
http://dx.doi.org/10.1073/pnas.2305556120

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