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Changing protein–DNA interactions promote ORC binding-site exchange during replication origin licensing
During origin licensing, the eukaryotic replicative helicase Mcm2-7 forms head-to-head double hexamers to prime origins for bidirectional replication. Recent single-molecule and structural studies revealed that one molecule of the helicase loader ORC (origin recognition complex) can sequentially loa...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372627/ https://www.ncbi.nlm.nih.gov/pubmed/37463200 http://dx.doi.org/10.1073/pnas.2305556120 |
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