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Small mitochondrial protein NERCLIN regulates cardiolipin homeostasis and mitochondrial ultrastructure

Cardiolipin (CL) is an essential phospholipid for mitochondrial structure and function. Here, we present a small mitochondrial protein, NERCLIN, as a negative regulator of CL homeostasis and mitochondrial ultrastructure. Primate-specific NERCLIN is expressed ubiquitously from the GRPEL2 locus on a t...

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Detalles Bibliográficos
Autores principales: Konovalova, Svetlana, Torregrosa-Muñumer, Rubén, Manjunath, Pooja, Liu, Xiaonan, Baral, Sundar, Fatima, Kaneez, Holopainen, Minna, Kvist, Jouni, Rajendran, Jayasimman, Yang, Yang, Varjosalo, Markku, Käkelä, Reijo, Somerharju, Pentti, Tyynismaa, Henna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372682/
https://www.ncbi.nlm.nih.gov/pubmed/37463214
http://dx.doi.org/10.1073/pnas.2210599120