Picomolar inhibitor of reverse transcriptase featuring significantly improved metabolic stability

Considering the undesirable metabolic stability of our recently identified NNRTI 5 (t(1/2) = 96 min) in human liver microsomes, we directed our efforts to improve its metabolic stability by introducing a new favorable hydroxymethyl side chain to the C-5 position of pyrimidine. This strategy provided...

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Detalles Bibliográficos
Autores principales: Sang, Ya-Li, Pannecouque, Christophe, De Clercq, Erik, Wang, Shuai, Chen, Fen-Er
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372819/
https://www.ncbi.nlm.nih.gov/pubmed/37521857
http://dx.doi.org/10.1016/j.apsb.2023.03.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372819/
https://www.ncbi.nlm.nih.gov/pubmed/37521857
http://dx.doi.org/10.1016/j.apsb.2023.03.022

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