A defective mechanosensing pathway affects fibroblast-to-myofibroblast transition in the old male mouse heart

The cardiac fibroblast interacts with an extracellular matrix (ECM), enabling myofibroblast maturation via a process called mechanosensing. Although in the aging male heart, ECM is stiffer than in the young mouse, myofibroblast development is impaired, as demonstrated in 2-D and 3-D experiments. In...

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Detalles Bibliográficos
Autores principales: Angelini, Aude, Trial, JoAnn, Saltzman, Alexander B., Malovannaya, Anna, Cieslik, Katarzyna A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372839/
https://www.ncbi.nlm.nih.gov/pubmed/37520701
http://dx.doi.org/10.1016/j.isci.2023.107283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372839/
https://www.ncbi.nlm.nih.gov/pubmed/37520701
http://dx.doi.org/10.1016/j.isci.2023.107283

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