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A defective mechanosensing pathway affects fibroblast-to-myofibroblast transition in the old male mouse heart
The cardiac fibroblast interacts with an extracellular matrix (ECM), enabling myofibroblast maturation via a process called mechanosensing. Although in the aging male heart, ECM is stiffer than in the young mouse, myofibroblast development is impaired, as demonstrated in 2-D and 3-D experiments. In...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372839/ https://www.ncbi.nlm.nih.gov/pubmed/37520701 http://dx.doi.org/10.1016/j.isci.2023.107283 |