ISLET: individual-specific reference panel recovery improves cell-type-specific inference

We propose a statistical framework ISLET to infer individual-specific and cell-type-specific transcriptome reference panels. ISLET models the repeatedly measured bulk gene expression data, to optimize the usage of shared information within each subject. ISLET is the first available method to achieve...

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Detalles Bibliográficos
Autores principales: Feng, Hao, Meng, Guanqun, Lin, Tong, Parikh, Hemang, Pan, Yue, Li, Ziyi, Krischer, Jeffrey, Li, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373385/
https://www.ncbi.nlm.nih.gov/pubmed/37496087
http://dx.doi.org/10.1186/s13059-023-03014-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373385/
https://www.ncbi.nlm.nih.gov/pubmed/37496087
http://dx.doi.org/10.1186/s13059-023-03014-8

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