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ISLET: individual-specific reference panel recovery improves cell-type-specific inference
We propose a statistical framework ISLET to infer individual-specific and cell-type-specific transcriptome reference panels. ISLET models the repeatedly measured bulk gene expression data, to optimize the usage of shared information within each subject. ISLET is the first available method to achieve...
Autores principales: | Feng, Hao, Meng, Guanqun, Lin, Tong, Parikh, Hemang, Pan, Yue, Li, Ziyi, Krischer, Jeffrey, Li, Qian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373385/ https://www.ncbi.nlm.nih.gov/pubmed/37496087 http://dx.doi.org/10.1186/s13059-023-03014-8 |
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