Discovery of a Hidden Trypanosoma cruzi Spermidine Synthase Binding Site and Inhibitors through In Silico, In Vitro, and X-ray Crystallography

[Image: see text] In drug discovery research, the selection of promising binding sites and understanding the binding mode of compounds are crucial fundamental studies. The current understanding of the proteins-ligand binding model extends beyond the simple lock and key model to include the induced-f...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoshino, Ryunosuke, Yasuo, Nobuaki, Hagiwara, Yohsuke, Ishida, Takashi, Inaoka, Daniel Ken, Amano, Yasushi, Tateishi, Yukihiro, Ohno, Kazuki, Namatame, Ichiji, Niimi, Tatsuya, Orita, Masaya, Kita, Kiyoshi, Akiyama, Yutaka, Sekijima, Masakazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373461/
https://www.ncbi.nlm.nih.gov/pubmed/37521650
http://dx.doi.org/10.1021/acsomega.3c01314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373461/
https://www.ncbi.nlm.nih.gov/pubmed/37521650
http://dx.doi.org/10.1021/acsomega.3c01314

Ejemplares similares