Exploration and Exploitation Approaches Based on Generative Machine Learning to Identify Potent Small Molecule Inhibitors of α-Synuclein Secondary Nucleation

[Image: see text] The high attrition rate in drug discovery pipelines is an especially pressing issue for Parkinson’s disease, for which no disease-modifying drugs have yet been approved. Numerous clinical trials targeting α-synuclein aggregation have failed, at least in part due to the challenges i...

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Detalles Bibliográficos
Autores principales: Horne, Robert I., Murtada, Mhd Hussein, Huo, Donghui, Brotzakis, Z. Faidon, Gregory, Rebecca C., Possenti, Andrea, Chia, Sean, Vendruscolo, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373478/
https://www.ncbi.nlm.nih.gov/pubmed/36939645
http://dx.doi.org/10.1021/acs.jctc.2c01303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373478/
https://www.ncbi.nlm.nih.gov/pubmed/36939645
http://dx.doi.org/10.1021/acs.jctc.2c01303

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