Accelerating Cryptic Pocket Discovery Using AlphaFold

[Image: see text] Cryptic pockets, or pockets absent in ligand-free, experimentally determined structures, hold great potential as drug targets. However, cryptic pocket openings are often beyond the reach of conventional biomolecular simulations because certain cryptic pocket openings involve slow m...

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Detalles Bibliográficos
Autores principales: Meller, Artur, Bhakat, Soumendranath, Solieva, Shahlo, Bowman, Gregory R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373493/
https://www.ncbi.nlm.nih.gov/pubmed/36948209
http://dx.doi.org/10.1021/acs.jctc.2c01189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373493/
https://www.ncbi.nlm.nih.gov/pubmed/36948209
http://dx.doi.org/10.1021/acs.jctc.2c01189

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