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Accelerating Cryptic Pocket Discovery Using AlphaFold
[Image: see text] Cryptic pockets, or pockets absent in ligand-free, experimentally determined structures, hold great potential as drug targets. However, cryptic pocket openings are often beyond the reach of conventional biomolecular simulations because certain cryptic pocket openings involve slow m...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373493/ https://www.ncbi.nlm.nih.gov/pubmed/36948209 http://dx.doi.org/10.1021/acs.jctc.2c01189 |